Evernimicin Binds Exclusively to the 50S Ribosomal Subunit and Inhibits Translation in Cell-Free Systems Derived from both Gram-Positive and Gram-Negative Bacteria

Evernimicin (SCH 27899) is a new antibiotic with activity against a wide spectrum of gram-positive bacteria and activity against some gram-negative bacteria. Previous metabolic labeling studies indicated that evernimicin specifically inhibited protein synthesis in Staphylococcus aureus. Using a susc...

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Bibliografiske detaljer
Main Authors:	McNicholas, Paul M., Najarian, David J., Mann, Paul A., Hesk, David, Hare, Roberta S., Shaw, Karen J., Black, Todd A.
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology 2000
Fag:	Mechanisms of Action: Physiological Effects
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC89832/ https://ncbi.nlm.nih.gov/pubmed/10770739
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Evernimicin Binds Exclusively to the 50S Ribosomal Subunit and Inhibits Translation in Cell-Free Systems Derived from both Gram-Positive and Gram-Negative Bacteria

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