Mutations in Ribosomal Protein L16 Conferring Reduced Susceptibility to Evernimicin (SCH27899): Implications for Mechanism of Action

A clinical isolate of Streptococcus pneumoniae (SP#5) that showed decreased susceptibility to evernimicin (MIC, 1.5 μg/ml) was investigated. A 4,255-bp EcoRI fragment cloned from SP#5 was identified by its ability to transform evernimicin-susceptible S. pneumoniae R6 (MIC, 0.03 μg/ml) such that the...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Adrian, Peter V., Zhao, Wenjun, Black, Todd A., Shaw, Karen J., Hare, Roberta S., Klugman, Keith P.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2000
Schlagworte:	Mechanisms of Resistance
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89755/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10681347/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.3.732-738.2000
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