pncA Mutations as a Major Mechanism of Pyrazinamide Resistance in Mycobacterium tuberculosis: Spread of a Monoresistant Strain in Quebec, Canada

Pyrazinamide (PZA) is an important first-line tuberculosis drug that is part of the currently used short-course tuberculosis chemotherapy. PZA is a prodrug that has to be converted to the active form pyrazinoic acid by pyrazinamidase (PZase) activity, encoded by the pncA gene of Mycobacterium tuberc...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Cheng, Shao-Ji, Thibert, Louise, Sanchez, Tracy, Heifets, Leonid, Zhang, Ying
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2000
Schlagworte:	Mechanisms of Resistance
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89721/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10681313/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.3.528-532.2000
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