Oligonucleotides Tethered to a Short Polyguanylic Acid Stretch Are Targeted to Macrophages: Enhanced Antiviral Activity of a Vesicular Stomatitis Virus-Specific Antisense Oligonucleotide

The poor membrane permeability of oligonucleotides is one of the major problems of antisense technology. Here we report the construction of designer oligonucleotides for targeted delivery to macrophages. The oligonucleotides tethered to a 10-mer poly(G) sequence at their 3′ ends were recognized by s...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Prasad, Vikram, Hashim, Shehla, Mukhopadhyay, Amitabha, Basu, Sandip K., Roy, Rajendra P.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1999
Soggetti:	Antiviral Agents
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89544/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10543748/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.11.2689
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