Oligonucleotides Tethered to a Short Polyguanylic Acid Stretch Are Targeted to Macrophages: Enhanced Antiviral Activity of a Vesicular Stomatitis Virus-Specific Antisense Oligonucleotide

The poor membrane permeability of oligonucleotides is one of the major problems of antisense technology. Here we report the construction of designer oligonucleotides for targeted delivery to macrophages. The oligonucleotides tethered to a 10-mer poly(G) sequence at their 3′ ends were recognized by s...

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Publié dans:	Antimicrob Agents Chemother
Auteurs principaux:	Prasad, Vikram, Hashim, Shehla, Mukhopadhyay, Amitabha, Basu, Sandip K., Roy, Rajendra P.
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1999
Sujets:	Antiviral Agents
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89544/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10543748/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.11.2689
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