Oligonucleotides Tethered to a Short Polyguanylic Acid Stretch Are Targeted to Macrophages: Enhanced Antiviral Activity of a Vesicular Stomatitis Virus-Specific Antisense Oligonucleotide

The poor membrane permeability of oligonucleotides is one of the major problems of antisense technology. Here we report the construction of designer oligonucleotides for targeted delivery to macrophages. The oligonucleotides tethered to a 10-mer poly(G) sequence at their 3′ ends were recognized by s...

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Опубліковано в::	Antimicrob Agents Chemother
Автори:	Prasad, Vikram, Hashim, Shehla, Mukhopadhyay, Amitabha, Basu, Sandip K., Roy, Rajendra P.
Формат:	Artigo
Мова:	Inglês
Опубліковано:	American Society for Microbiology (ASM) 1999
Предмети:	Antiviral Agents
Онлайн доступ:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89544/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10543748/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.11.2689
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