Novel Expansions of the Gene Encoding Dihydropteroate Synthase in Trimethoprim-Sulfamethoxazole-Resistant Streptococcus pneumoniae

A study of eight sulfonamide-resistant clinical isolates of Streptococcus pneumoniae revealed chromosomal mutations within the gene encoding dihydropteroate synthase that play a role in conferring resistance to sulfamethoxazole. The presence of the suld mutation, found previously only in a laborator...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Padayachee, Thanugarani, Klugman, Keith P.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1999
Schlagworte:	Mechanisms of Resistance
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89451/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10471569/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.9.2225
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