Use of the Hepatitis B Virus Recombinant Baculovirus-HepG2 System to Study the Effects of (−)-β-2′,3′-Dideoxy-3′-Thiacytidine on Replication of Hepatitis B Virus and Accumulation of Covalently Closed Circular DNA

(−)-β-2′,3′-Dideoxy-3′-thiacytidine (lamivudine [3TC]) is a nucleoside analog which effectively interferes with the replication of hepatitis B virus (HBV) DNA in vitro and in vivo. We have investigated the antiviral properties of 3TC in vitro in HepG2 cells infected with recombinant HBV baculovirus....

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Delaney, William E., Miller, Thomas G., Isom, Harriet C.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Antiviral Agents
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89407/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10428929/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.8.2017
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