Unusual Antimicrotubule Activity of the Antifungal Agent Spongistatin 1

Spongistatin 1, a macrocyclic lactone from the marine sponge Hyrtios erecta, has broad-spectrum antifungal activity. Since this compound is a potent antimicrotubule agent in mammalian cells, we examined its effects on the filamentous fungus Aspergillus nidulans to determine if its antifungal effects...

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Autors principals: Ovechkina, Yulia Y., Pettit, Robin K., Cichacz, Zbigniew A., Pettit, George R., Oakley, Berl R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1999
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Mechanisms of Action: Physiological Effects
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC89403/
https://ncbi.nlm.nih.gov/pubmed/10428925
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