Unusual Antimicrotubule Activity of the Antifungal Agent Spongistatin 1

Spongistatin 1, a macrocyclic lactone from the marine sponge Hyrtios erecta, has broad-spectrum antifungal activity. Since this compound is a potent antimicrotubule agent in mammalian cells, we examined its effects on the filamentous fungus Aspergillus nidulans to determine if its antifungal effects...

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Bibliographic Details

Published in:	Antimicrob Agents Chemother
Main Authors:	Ovechkina, Yulia Y., Pettit, Robin K., Cichacz, Zbigniew A., Pettit, George R., Oakley, Berl R.
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology (ASM) 1999
Subjects:	Mechanisms of Action: Physiological Effects
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89403/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10428925/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.8.1993
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