Resistance to β-Lactam Antibiotics in Pseudomonas aeruginosa Due to Interplay between the MexAB-OprM Efflux Pump and β-Lactamase

We evaluated the roles of the MexAB-OprM efflux pump and β-lactamase in β-lactam resistance in Pseudomonas aeruginosa by constructing OprM-deficient, OprM basal level, and OprM fully expressed mutants from β-lactamase-negative, -inducible, and -overexpressed strains. We conclude that, with the notab...

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Hlavní autoři: Nakae, Taiji, Nakajima, Akira, Ono, Toshihisa, Saito, Kohjiro, Yoneyama, Hiroshi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 1999
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC89266/
https://ncbi.nlm.nih.gov/pubmed/10223959
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