Declining Concentrations of Dihydroartemisinin in Plasma during 5-Day Oral Treatment with Artesunate for Falciparum Malaria

Six patients with uncomplicated falciparum malaria received artesunate for 5 days. Plasma concentrations of artesunate and dihydroartemisinin were determined by high-performance liquid chromatography with electrochemical detection. The concentrations of dihydroartemisinin in plasma 2 h after a dose...

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Autors principals: Khanh, Nguyen Xuan, de Vries, Peter J., Ha, Le Dang, van Boxtel, Chris J., Koopmans, Richard, Kager, Piet A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1999
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC89184/
https://ncbi.nlm.nih.gov/pubmed/10049291
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