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Fluoroquinolone Action against Clinical Isolates of Mycobacterium tuberculosis: Effects of a C-8 Methoxyl Group on Survival in Liquid Media and in Human Macrophages

When the lethal action of a C-8 methoxyl fluoroquinolone against clinical isolates of Mycobacterium tuberculosis in liquid medium was measured, the compound was found to be three to four times more effective (as determined by measuring the 90% lethal dose) than a C-8-H control fluoroquinolone or cip...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Principais autores: Zhao, Ben Yang, Pine, Richard, Domagala, John, Drlica, Karl
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1999
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89177/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10049284/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.3.661
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