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Role of Superoxide in Catalase-Peroxidase-Mediated Isoniazid Action against Mycobacteria

Isoniazid (INH) activation in vitro is associated with reduction of the mycobacterial ferric KatG catalase-peroxidase by hydrazine and reaction with O(2) to form an oxyferrous enzyme complex. Since this complex could also form directly via reaction of ferric KatG with superoxide, intracellular activ...

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Bibliografiset tiedot
Päätekijät: Wang, Jian-Ying, Burger, Richard M., Drlica, Karl
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 1998
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC105525/
https://ncbi.nlm.nih.gov/pubmed/9517959
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