Role of Superoxide in Catalase-Peroxidase-Mediated Isoniazid Action against Mycobacteria

Isoniazid (INH) activation in vitro is associated with reduction of the mycobacterial ferric KatG catalase-peroxidase by hydrazine and reaction with O(2) to form an oxyferrous enzyme complex. Since this complex could also form directly via reaction of ferric KatG with superoxide, intracellular activ...

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Dades bibliogràfiques

Publicat a:	Antimicrob Agents Chemother
Autors principals:	Wang, Jian-Ying, Burger, Richard M., Drlica, Karl
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology (ASM) 1998
Matèries:	Mechanisms of Action: Physiological Effects
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105525/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9517959/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.3.709
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