Role of Superoxide in Catalase-Peroxidase-Mediated Isoniazid Action against Mycobacteria

Isoniazid (INH) activation in vitro is associated with reduction of the mycobacterial ferric KatG catalase-peroxidase by hydrazine and reaction with O(2) to form an oxyferrous enzyme complex. Since this complex could also form directly via reaction of ferric KatG with superoxide, intracellular activ...

Cijeli opis

Bibliografski detalji

Izdano u:	Antimicrob Agents Chemother
Glavni autori:	Wang, Jian-Ying, Burger, Richard M., Drlica, Karl
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology (ASM) 1998
Teme:	Mechanisms of Action: Physiological Effects
Online pristup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105525/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9517959/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.3.709
Oznake:	Dodaj oznaku Bez oznaka, Budi prvi tko označuje ovaj zapis!