Structure-Function Studies of Ser-289 in the Class C β-Lactamase from Enterobacter cloacae P99

Site-directed mutagenesis of Ser-289 of the class C β-lactamase from Enterobacter cloacae P99 was performed to investigate the role of this residue in β-lactam hydrolysis. This amino acid lies near the active site of the enzyme, where it can interact with the C-3 substituent of cephalosporins. Kinet...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Trépanier, Sonia, Knox, James R., Clairoux, Natalie, Sanschagrin, François, Levesque, Roger C., Huletsky, Ann
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1999
Schlagworte:	Mechanisms of Resistance
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89158/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10049265/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.3.543
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