Influences of Urinary pH on Ciprofloxacin Pharmacokinetics in Humans and Antimicrobial Activity In Vitro versus Those of Sparfloxacin

The impact of acidification and alkalinization of urine on the pharmacokinetics of ciprofloxacin was investigated after single 200-mg oral doses were administered to nine healthy male volunteers. In addition, the effect of human urine on the MICs of ciprofloxacin and sparfloxacin against some common...

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הוצא לאור ב:	Antimicrob Agents Chemother
Principais autores:	Kamberi, Marika, Tsutsumi, Kimiko, Kotegawa, Tsutomu, Kawano, Koichi, Nakamura, Koichi, Niki, Yoshihito, Nakano, Shigeyuki
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	American Society for Microbiology (ASM) 1999
נושאים:	Pharmacology
גישה מקוונת:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89155/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10049262/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.3.525
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