Influences of Urinary pH on Ciprofloxacin Pharmacokinetics in Humans and Antimicrobial Activity In Vitro versus Those of Sparfloxacin

The impact of acidification and alkalinization of urine on the pharmacokinetics of ciprofloxacin was investigated after single 200-mg oral doses were administered to nine healthy male volunteers. In addition, the effect of human urine on the MICs of ciprofloxacin and sparfloxacin against some common...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Kamberi, Marika, Tsutsumi, Kimiko, Kotegawa, Tsutomu, Kawano, Koichi, Nakamura, Koichi, Niki, Yoshihito, Nakano, Shigeyuki
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Pharmacology
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89155/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10049262/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.3.525
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