ParC and GyrA May Be Interchangeable Initial Targets of Some Fluoroquinolones in Streptococcus pneumoniae

To evaluate the role of known topoisomerase IV and gyrase mutations in the fluoroquinolone (FQ) resistance of Streptococcus pneumoniae, we transformed susceptible strain R6 with PCR-generated fragments encompassing the quinolone resistance-determining regions (QRDRs) of parC or gyrA from different r...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Varon, Emmanuelle, Janoir, Claire, Kitzis, Marie-Dominique, Gutmann, Laurent
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Mechanisms of Resistance
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89068/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9925523/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.2.302
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