Identification of an Efflux Pump Gene, pmrA, Associated with Fluoroquinolone Resistance in Streptococcus pneumoniae

An open reading frame (ORF) homologous to norA was insertionally inactivated with cat in a fluoroquinolone-resistant pneumococcus with an efflux phenotype; this inactivation caused reversion to drug sensitivity. The ORF product has 24% amino acid sequence identity each to NorA and Bmr, which suggest...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Gill, Martin J., Brenwald, Nigel P., Wise, Richard
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1999
Soggetti:	Mechanisms of Resistance
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89047/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9869592/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.1.187
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