Identification of an Efflux Pump Gene, pmrA, Associated with Fluoroquinolone Resistance in Streptococcus pneumoniae

An open reading frame (ORF) homologous to norA was insertionally inactivated with cat in a fluoroquinolone-resistant pneumococcus with an efflux phenotype; this inactivation caused reversion to drug sensitivity. The ORF product has 24% amino acid sequence identity each to NorA and Bmr, which suggest...

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Bibliographic Details
Main Authors: Gill, Martin J., Brenwald, Nigel P., Wise, Richard
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1999
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC89047/
https://ncbi.nlm.nih.gov/pubmed/9869592
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