ADP-Ribosylation as an Intermediate Step in Inactivation of Rifampin by a Mycobacterial Gene

Mycobacterium smegmatis DSM43756 inactivates rifampin, and the inactivated antibiotic product recovered from culture medium was ribosylated on the 23-OH group. To study this process, the gene responsible for the inactivation was expressed at high levels by the lac promoter in Escherichia coli confer...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Quan, Selwyn, Imai, Tamae, Mikami, Yuzuru, Yazawa, Katsukiyo, Dabbs, Eric R., Morisaki, Naoko, Iwasaki, Shigeo, Hashimoto, Yuichi, Furihata, Kazuo
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1999
Schlagworte:	Mechanisms of Resistance
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89045/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9869590/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.1.181
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