ADP-Ribosylation as an Intermediate Step in Inactivation of Rifampin by a Mycobacterial Gene

Mycobacterium smegmatis DSM43756 inactivates rifampin, and the inactivated antibiotic product recovered from culture medium was ribosylated on the 23-OH group. To study this process, the gene responsible for the inactivation was expressed at high levels by the lac promoter in Escherichia coli confer...

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Detalhes bibliográficos
Main Authors: Quan, Selwyn, Imai, Tamae, Mikami, Yuzuru, Yazawa, Katsukiyo, Dabbs, Eric R., Morisaki, Naoko, Iwasaki, Shigeo, Hashimoto, Yuichi, Furihata, Kazuo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1999
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC89045/
https://ncbi.nlm.nih.gov/pubmed/9869590
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