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CDK9 Autophosphorylation Regulates High-Affinity Binding of the Human Immunodeficiency Virus Type 1 Tat–P-TEFb Complex to TAR RNA

Human immunodeficiency virus type 1 (HIV-1) Tat interacts with cyclin T1 (CycT1), a regulatory partner of CDK9 in the positive transcription elongation factor (P-TEFb) complex, and binds cooperatively with CycT1 to TAR RNA to recruit P-TEFb and promote transcription elongation. We show here that Tat...

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Udgivet i:Mol Cell Biol
Principais autores: Garber, Mitchell E., Mayall, Timothy P., Suess, Eric M., Meisenhelder, Jill, Thompson, Nancy E., Jones, Katherine A.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2000
Fag:
Transcriptional Regulation
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC88771/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10958691/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.18.6958-6969.2000
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