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Impact of Genetic Variations in HIV-1 Tat on LTR-Mediated Transcription via TAR RNA Interaction

HIV-1 evades host defense through mutations and recombination events, generating numerous variants in an infected patient. These variants with an undiminished virulence can multiply rapidly in order to progress to AIDS. One of the targets to intervene in HIV-1 replication is the trans-activator of t...

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Principais autores: Larance Ronsard, Akhil C. Banerjea, Nilanjana Ganguli, Vivek K. Singh, Kumaravel Mohankumar, Tripti Rai, Subhashree Sridharan, Sankar Pajaniradje, Binod Kumar, Devesh Rai, Suhnrita Chaudhuri, Mohane S. Coumar, Vishnampettai G. Ramachandran
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017-04-01
coleção:Frontiers in Microbiology
Assuntos:
HIV-1 Tat
transactivation
TAR RNA
genetic variations
recombination
mutations
Acesso em linha:http://journal.frontiersin.org/article/10.3389/fmicb.2017.00706/full
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