Design of TAT-Conjugated Bowman–Birk Trypsin Inhibitor Peptides with Enhanced Antimicrobial and Antiproliferative Activities

Cell-penetrating peptide (CPP) conjugation represents a promising strategy for enhancing the biological activity of therapeutic peptides. In this study, three analogues were designed by conjugating the trypsin inhibitory loop (TIL) derived from a Bowman–Birk-type inhibitor with the transactivator of...

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Bibliographic Details

Main Authors:	Ying Wang, Yangyang Jiang, Tao Wang, Xiaoling Chen, Lei Wang, Mei Zhou, James F. Burrows, Tianbao Chen, Xiaofei Zhang, Na Li
Format:	Artigo
Language:	Inglês
Published:	MDPI AG 2026-03-01
Series:	Biomolecules
Subjects:	Bowman–Birk type inhibitors the transactivator of transcription (TAT) peptide linker antimicrobial activity antiproliferative activity
Online Access:	https://www.mdpi.com/2218-273X/16/4/511
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