Design of TAT-Conjugated Bowman–Birk Trypsin Inhibitor Peptides with Enhanced Antimicrobial and Antiproliferative Activities

Cell-penetrating peptide (CPP) conjugation represents a promising strategy for enhancing the biological activity of therapeutic peptides. In this study, three analogues were designed by conjugating the trypsin inhibitory loop (TIL) derived from a Bowman–Birk-type inhibitor with the transactivator of...

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Autori principali:	Ying Wang, Yangyang Jiang, Tao Wang, Xiaoling Chen, Lei Wang, Mei Zhou, James F. Burrows, Tianbao Chen, Xiaofei Zhang, Na Li
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2026-03-01
Serie:	Biomolecules
Soggetti:	Bowman–Birk type inhibitors the transactivator of transcription (TAT) peptide linker antimicrobial activity antiproliferative activity
Accesso online:	https://www.mdpi.com/2218-273X/16/4/511
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