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β-Catenin–Histone Deacetylase Interactions Regulate the Transition of LEF1 from a Transcriptional Repressor to an Activator

Recent evidence suggests that certain LEF/TCF family members act as repressors in the absence of Wnt signaling. We show here that repression by LEF1 requires histone deacetylase (HDAC) activity. Further, LEF1 associates in vivo with HDAC1, and transcription of a model LEF1-dependent target gene is m...

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Udgivet i:Mol Cell Biol
Principais autores: Billin, Andrew N., Thirlwell, Hilary, Ayer, Donald E.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2000
Fag:
Transcriptional Regulation
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC88764/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10958684/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.18.6882-6890.2000
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