β-Catenin–Histone Deacetylase Interactions Regulate the Transition of LEF1 from a Transcriptional Repressor to an Activator

Recent evidence suggests that certain LEF/TCF family members act as repressors in the absence of Wnt signaling. We show here that repression by LEF1 requires histone deacetylase (HDAC) activity. Further, LEF1 associates in vivo with HDAC1, and transcription of a model LEF1-dependent target gene is m...

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Detalles Bibliográficos

Publicado en:	Mol Cell Biol
Autores principales:	Billin, Andrew N., Thirlwell, Hilary, Ayer, Donald E.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis 2000
Materias:	Transcriptional Regulation
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC88764/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10958684/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.18.6882-6890.2000
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