β-Catenin–Histone Deacetylase Interactions Regulate the Transition of LEF1 from a Transcriptional Repressor to an Activator

Recent evidence suggests that certain LEF/TCF family members act as repressors in the absence of Wnt signaling. We show here that repression by LEF1 requires histone deacetylase (HDAC) activity. Further, LEF1 associates in vivo with HDAC1, and transcription of a model LEF1-dependent target gene is m...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Billin, Andrew N., Thirlwell, Hilary, Ayer, Donald E.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2000
Assuntos:	Transcriptional Regulation
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC88764/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10958684/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.18.6882-6890.2000
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