Relationship between Mutations in Dihydropteroate Synthase of Pneumocystis carinii f. sp. hominis Isolates in Japan and Resistance to Sulfonamide Therapy

We examined mutations in the dihydropteroate synthase (DHPS) genes of Pneumocystis carinii f. sp. hominis (P. carinii) strains isolated from 24 patients with P. carinii pneumonia (PCP) in Japan. DHPS mutations were identified at amino acid positions 55 and/or 57 in isolates from 6 (25.0%) of 24 pati...

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Autori principali: Takahashi, Takashi, Hosoya, Noriaki, Endo, Tokiomi, Nakamura, Tetsuya, Sakashita, Hiroyuki, Kimura, Kyoko, Ohnishi, Kenji, Nakamura, Yoshikazu, Iwamoto, Aikichi
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2000
Soggetti:
Mycology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC87344/
https://ncbi.nlm.nih.gov/pubmed/10970350
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