Relationship between Mutations in Dihydropteroate Synthase of Pneumocystis carinii f. sp. hominis Isolates in Japan and Resistance to Sulfonamide Therapy

We examined mutations in the dihydropteroate synthase (DHPS) genes of Pneumocystis carinii f. sp. hominis (P. carinii) strains isolated from 24 patients with P. carinii pneumonia (PCP) in Japan. DHPS mutations were identified at amino acid positions 55 and/or 57 in isolates from 6 (25.0%) of 24 pati...

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Auteurs principaux: Takahashi, Takashi, Hosoya, Noriaki, Endo, Tokiomi, Nakamura, Tetsuya, Sakashita, Hiroyuki, Kimura, Kyoko, Ohnishi, Kenji, Nakamura, Yoshikazu, Iwamoto, Aikichi
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2000
Sujets:
Mycology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC87344/
https://ncbi.nlm.nih.gov/pubmed/10970350
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