Relationship between Mutations in Dihydropteroate Synthase of Pneumocystis carinii f. sp. hominis Isolates in Japan and Resistance to Sulfonamide Therapy

We examined mutations in the dihydropteroate synthase (DHPS) genes of Pneumocystis carinii f. sp. hominis (P. carinii) strains isolated from 24 patients with P. carinii pneumonia (PCP) in Japan. DHPS mutations were identified at amino acid positions 55 and/or 57 in isolates from 6 (25.0%) of 24 pati...

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Main Authors: Takahashi, Takashi, Hosoya, Noriaki, Endo, Tokiomi, Nakamura, Tetsuya, Sakashita, Hiroyuki, Kimura, Kyoko, Ohnishi, Kenji, Nakamura, Yoshikazu, Iwamoto, Aikichi
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2000
主題:
Mycology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC87344/
https://ncbi.nlm.nih.gov/pubmed/10970350
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