Targeting of the c-Abl Tyrosine Kinase to Mitochondria in Endoplasmic Reticulum Stress-Induced Apoptosis

The ubiquitously expressed c-Abl tyrosine kinase localizes to the nucleus and cytoplasm. Using confocal microscopy, we demonstrated that c-Abl colocalizes with the endoplasmic reticulum (ER)-associated protein grp78. Expression of c-Abl in the ER was confirmed by immunoelectron microscopy. Subcellul...

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Autors principals: Ito, Yasumasa, Pandey, Pramod, Mishra, Neerad, Kumar, Shailendra, Narula, Navneet, Kharbanda, Surender, Saxena, Satya, Kufe, Donald
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2001
Matèries:
Cell Growth and Development
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC87342/
https://ncbi.nlm.nih.gov/pubmed/11509666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.18.6233-6242.2001
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