Signal Pathways Which Promote Invasion and Metastasis: Critical and Distinct Contributions of Extracellular Signal-Regulated Kinase and Ral-Specific Guanine Exchange Factor Pathways

Approximately 50% of metastatic tumors contain Ras mutations. Ras proteins can activate at least three downstream signaling cascades mediated by the Raf–MEK–extracellular signal-regulated kinase family, phosphatidylinositol-3 (PI3) kinase, and Ral-specific guanine nucleotide exchange factors (RalGEF...

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Main Authors: Ward, Yvona, Wang, Warner, Woodhouse, Elisa, Linnoila, Ilona, Liotta, Lance, Kelly, Kathleen
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2001
Assuntos:
Cell Growth and Development
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC87314/
https://ncbi.nlm.nih.gov/pubmed/11486034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.17.5958-5969.2001
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