High-Copy-Number Expression of Sub2p, a Member of the RNA Helicase Superfamily, Suppresses hpr1-Mediated Genomic Instability

We report on a novel role for a pre-mRNA splicing component in genome stability. The Hpr1 protein, a component of an RNA polymerase II complex and required for transcription elongation, is also required for genome stability. Deletion of HPR1 results in a 1,000-fold increase in genome instability, de...

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Detalles Bibliográficos

Publicado en:	Mol Cell Biol
Autores principales:	Fan, Hua-Ying, Merker, Robert J., Klein, Hannah L.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis 2001
Materias:	DNA Dynamics and Chromosome Structure
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC87268/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11463828/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.16.5459-5470.2001
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