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High-Copy-Number Expression of Sub2p, a Member of the RNA Helicase Superfamily, Suppresses hpr1-Mediated Genomic Instability

We report on a novel role for a pre-mRNA splicing component in genome stability. The Hpr1 protein, a component of an RNA polymerase II complex and required for transcription elongation, is also required for genome stability. Deletion of HPR1 results in a 1,000-fold increase in genome instability, de...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Fan, Hua-Ying, Merker, Robert J., Klein, Hannah L.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2001
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC87268/
https://ncbi.nlm.nih.gov/pubmed/11463828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.16.5459-5470.2001
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