Nucleocytoplasmic Distribution of the Ovalbumin Serpin PI-9 Requires a Nonconventional Nuclear Import Pathway and the Export Factor Crm1

Proteinase inhibitor 9 (PI-9) is a human serpin present in the cytoplasm of cytotoxic lymphocytes and epithelial cells. It inhibits the cytotoxic lymphocyte granule proteinase granzyme B (graB) and is thought to protect cytotoxic lymphocytes and bystander cells from graB-mediated apoptosis. Followin...

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Autors principals: Bird, Catherina H., Blink, Elizabeth J., Hirst, Claire E., Buzza, Marguerite S., Steele, Pauline M., Sun, Jiuru, Jans, David A., Bird, Phillip I.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2001
Matèries:
Nucleocytoplasmic Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC87262/
https://ncbi.nlm.nih.gov/pubmed/11463822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.16.5396-5407.2001
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