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Nucleocytoplasmic Distribution of the Ovalbumin Serpin PI-9 Requires a Nonconventional Nuclear Import Pathway and the Export Factor Crm1

Proteinase inhibitor 9 (PI-9) is a human serpin present in the cytoplasm of cytotoxic lymphocytes and epithelial cells. It inhibits the cytotoxic lymphocyte granule proteinase granzyme B (graB) and is thought to protect cytotoxic lymphocytes and bystander cells from graB-mediated apoptosis. Followin...

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Udgivet i:Mol Cell Biol
Principais autores: Bird, Catherina H., Blink, Elizabeth J., Hirst, Claire E., Buzza, Marguerite S., Steele, Pauline M., Sun, Jiuru, Jans, David A., Bird, Phillip I.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2001
Fag:
Nucleocytoplasmic Communication
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC87262/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11463822/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.16.5396-5407.2001
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