Mammalian Target of Rapamycin Pathway Regulates Insulin Signaling via Subcellular Redistribution of Insulin Receptor Substrate 1 and Integrates Nutritional Signals and Metabolic Signals of Insulin

A pathway sensitive to rapamycin, a selective inhibitor of mammalian target of rapamycin (mTOR), down-regulates effects of insulin such as activation of Akt (protein kinase B) via proteasomal degradation of insulin receptor substrate 1 (IRS-1). We report here that the pathway also plays an important...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Takano, Atsuko, Usui, Isao, Haruta, Tetsuro, Kawahara, Junko, Uno, Tatsuhito, Iwata, Minoru, Kobayashi, Masashi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2001
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC87231/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11438661/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.15.5050-5062.2001
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