Mammalian Target of Rapamycin Pathway Regulates Insulin Signaling via Subcellular Redistribution of Insulin Receptor Substrate 1 and Integrates Nutritional Signals and Metabolic Signals of Insulin

A pathway sensitive to rapamycin, a selective inhibitor of mammalian target of rapamycin (mTOR), down-regulates effects of insulin such as activation of Akt (protein kinase B) via proteasomal degradation of insulin receptor substrate 1 (IRS-1). We report here that the pathway also plays an important...

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Detalhes bibliográficos
Main Authors: Takano, Atsuko, Usui, Isao, Haruta, Tetsuro, Kawahara, Junko, Uno, Tatsuhito, Iwata, Minoru, Kobayashi, Masashi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC87231/
https://ncbi.nlm.nih.gov/pubmed/11438661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.15.5050-5062.2001
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