Identification of rad27 Mutations That Confer Differential Defects in Mutation Avoidance, Repeat Tract Instability, and Flap Cleavage

In eukaryotes, the nuclease activity of Rad27p (Fen1p) is thought to play a critical role in lagging-strand DNA replication by removing ribonucleotides present at the 5′ ends of Okazaki fragments. Genetic analysis of Saccharomyces cerevisiae also has identified a role for Rad27p in mutation avoidanc...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Xie, Yali, Liu, Yuan, Argueso, Juan Lucas, Henricksen, Leigh A., Kao, Hui-I, Bambara, Robert A., Alani, Eric
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2001
Sujets:
DNA Dynamics and Chromosome Structure
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC87203/
https://ncbi.nlm.nih.gov/pubmed/11438646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.15.4889-4899.2001
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