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Schizosaccharomyces pombe Cells Lacking the Amino-Terminal Catalytic Domains of DNA Polymerase Epsilon Are Viable but Require the DNA Damage Checkpoint Control

In Schizosaccharomyces pombe, the catalytic subunit of DNA polymerase epsilon (Pol ɛ) is encoded by cdc20(+) and is essential for chromosomal DNA replication. Here we demonstrate that the N-terminal half of Pol ɛ that includes the highly conserved polymerase and exonuclease domains is dispensable fo...

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Udgivet i:Mol Cell Biol
Principais autores: Feng, Wenyi, D'Urso, Gennaro
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2001
Fag:
DNA Dynamics and Chromosome Structure
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC87109/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11416129/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.14.4495-4504.2001
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