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Schizosaccharomyces pombe Cells Lacking the Amino-Terminal Catalytic Domains of DNA Polymerase Epsilon Are Viable but Require the DNA Damage Checkpoint Control
In Schizosaccharomyces pombe, the catalytic subunit of DNA polymerase epsilon (Pol ɛ) is encoded by cdc20(+) and is essential for chromosomal DNA replication. Here we demonstrate that the N-terminal half of Pol ɛ that includes the highly conserved polymerase and exonuclease domains is dispensable fo...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Microbiology
2001
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC87109/ https://ncbi.nlm.nih.gov/pubmed/11416129 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.14.4495-4504.2001 |
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