Impaired DNA Damage Response in Cells Expressing an Exon 11-Deleted Murine Brca1 Variant That Localizes to Nuclear Foci

Both human and mouse cells express an alternatively spliced variant of BRCA1, BRCA1-Δ11, which lacks exon 11 in its entirety, including putative nuclear localization signals. Consistent with this, BRCA1-Δ11 has been reported to reside in the cytoplasm, a localization that would ostensibly preclude i...

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Autors principals: Huber, L. Julie, Yang, Thomas W., Sarkisian, Christopher J., Master, Stephen R., Deng, Chu-Xia, Chodosh, Lewis A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2001
Matèries:
DNA Dynamics and Chromosome Structure
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC87063/
https://ncbi.nlm.nih.gov/pubmed/11359908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.12.4005-4015.2001
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