BRCA2 Is Ubiquitinated In Vivo and Interacts with USP11, a Deubiquitinating Enzyme That Exhibits Prosurvival Function in the Cellular Response to DNA Damage

Individuals carrying a germ line mutation of the breast cancer susceptibility gene BRCA2 are predisposed to breast, ovarian, and other types of cancer. The BRCA2 protein has been proposed to function in the repair of DNA double-strand breaks. Using an immunopurification-mass spectrometry approach to...

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Detalhes bibliográficos
Main Authors: Schoenfeld, Alan R., Apgar, Sarah, Dolios, Georgia, Wang, Rong, Aaronson, Stuart A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC506974/
https://ncbi.nlm.nih.gov/pubmed/15314155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.17.7444-7455.2004
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