Brca2 (XRCC11) Deficiency Results in Radioresistant DNA Synthesis and a Higher Frequency of Spontaneous Deletions

We show here that the radiosensitive Chinese hamster cell mutant (V-C8) of group XRCC11 is defective in the breast cancer susceptibility gene Brca2. The very complex phenotype of V-C8 cells is complemented by a single human chromosome 13 providing the BRCA2 gene, as well as by the murine Brca2 gene....

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Detalhes bibliográficos
Main Authors: Kraakman-van der Zwet, Maria, Overkamp, Wilhelmina J. I., van Lange, Rebecca E. E., Essers, Jeroen, van Duijn-Goedhart, Annemarie, Wiggers, Ingrid, Swaminathan, Srividya, van Buul, Paul P. W., Errami, Abdellatif, Tan, Raoul T. L., Jaspers, Nicolaas G. J., Sharan, Shyam K., Kanaar, Roland, Zdzienicka, Małgorzata Z.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC139737/
https://ncbi.nlm.nih.gov/pubmed/11756561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.2.669-679.2002
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