Negative Regulation of CD4 Gene Expression by a HES-1–c-Myb Complex

Expression of the CD4 gene is tightly controlled throughout thymopoiesis. The downregulation of CD4 gene expression in CD4(−) CD8(−) and CD4(−) CD8(+) T lymphocytes is controlled by a transcriptional silencer located in the first intron of the CD4 locus. Here, we determine that the c-Myb transcripti...

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Bibliografiske detaljer
Main Authors: Allen, Robert D., Kim, Han K., Sarafova, Sophia D., Siu, Gerald
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2001
Fag:
Transcriptional Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC86935/
https://ncbi.nlm.nih.gov/pubmed/11287612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.9.3071-3082.2001
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