Thrombopoietin-Mediated Sustained Activation of Extracellular Signal-Regulated Kinase in UT7-Mpl Cells Requires Both Ras–Raf-1- and Rap1–B-Raf-Dependent Pathways

Thrombopoietin (TPO) regulates growth and differentiation of megakaryocytes. We previously showed that extracellular signal-regulated kinases (ERKs) are required for TPO-mediated full megakaryocytic maturation in both normal progenitors and a megakaryoblastic cell line (UT7) expressing the TPO recep...

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Bibliographische Detailangaben
Hauptverfasser: Garcia, Josefina, de Gunzburg, Jean, Eychène, Alain, Gisselbrecht, Sylvie, Porteu, Françoise
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2001
Schlagworte:
Cell Growth and Development
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC86897/
https://ncbi.nlm.nih.gov/pubmed/11283246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.8.2659-2670.2001
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