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Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling.

The small GTPase Rap1 has been implicated in both negative and positive control of Ras-mediated signalling events. We have investigated which extracellular signals can activate Rap1 and whether this activation leads to a modulation of Ras effector signalling, i.e. the activation of ERK and the small...

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Autori principali: Zwartkruis, F J, Wolthuis, R M, Nabben, N M, Franke, B, Bos, J L
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1998
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170918/
https://ncbi.nlm.nih.gov/pubmed/9774335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.20.5905
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